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Clin Cancer Res 10 : 67796788 Acknowledgements This research was supported by Novartis Pharma AG

Cell permeability assay For each 3CL inhibitor, HEK-293T cells were seeded at 1 million cells per well into 6 wells of a 6-well plate and incubated overnight

The pharmacophore of withanolides is found to be associated with the induction of cytoprotective heat-shock response (Wijeratne et al., 2014) and inhibition of HSP90 (Gu et al., 2014)

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298,299 The human genome encodes more than 600 E3 ligases, underscoring the vast diversity and specificity of substrates targeted by the UPS

The control values did not differ significantly between the two terms of sacrifice