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XLSA/A is an early onset disease characterised by a blood disorder in which erythrocytes do not produce enough haemoglobin (sideroblastic anemia) and slow-progressive movement problems (slow-progressive ataxia) [99]
It was discovered that DFO administration dramatically maintained liver function and reversed hepatic histopathological lesions and iron accumulation in rats
The number of animals assigned per condition was selected to account for the variability of the examined phenotypes based on pilot experiment and past experience with the animal models (6 animals per experimental condition)
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