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The exceptional sensitivity of brain mitochondria to copper
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After 48 h, the mice were sacrificed, and the heart, liver, spleen, lung, kidney, and tumor tissues were subsequently isolated, weighed, and nitrated for further analysis
These downstream effects contribute to neuroinflammation and neuronal loss, thereby reinforcing the pathological association between E2 decline, mitochondrial dysfunction and mood disorders during perimenopause (131)
