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CTCs need to break through the blood-brain barrier (BBB), interplay with the local microenvironment to survive, and then set up brain metastatic colonies

For transfection, cells were transiently transfected with plasmid and siRNAs, using Lipo6000 Transfection Reagent (Beyotime, Shanghai, China) according to the manufacturers protocol

Teneurin C-terminal Associated Peptide (TCAP)-1, a naturally occurring neuropeptide, is an established regulator of corticotropin-releasing factor (CRF) mediated stress responses

Internal FDA funding

As a consequence, BDNF became a key target in the physiopathology of several neurological and psychiatric diseases

Increased proton pump expression in oesophageal tissue may also contribute to local acid secretion, causing inflammation, mitochondrial damage and, ultimately, carcinogenesis (Reference Stabenau, Samuels and Lam31)