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S., Heavens, N

The 6 subunit exhibits specific expression in VTA dopamine neurons and their striatal terminals, co-assembling with the 3 subunit to form high calcium permeability complexes: ( 6 2 ) 2 3 and ( 4 2 )( 6 2 ) 3 ( 6 knockout mice exhibit abolished motivation for nicotine intake in both acute nicotine self-administration and two-bottle choice paradigms ( 3 subunit serves as an auxiliary component of 6 -containing receptors, enhancing nicotines regulation of striatal dopamine release by promoting receptor maturation and membrane localization ( 3 subunit reduces 6 receptor expression in the striatum and attenuates nicotine-induced dopamine release, while allelic variations in the CHRNB3 gene cluster show significant association with nicotine addiction risk ( 5 subunit incorporates into 4 2 receptors as a non-ligand-binding auxiliary subunit, forming ( 4 2 ) 2 5 complexes that exhibit enhanced calcium permeability compared to classical 4 2 receptors and demonstrate resistance to agonist-induced desensitization ( 5 -knockout mice exhibit attenuated responsiveness to nicotine ( 5 receptor primarily regulates dopamine release in the dorsal striatum, demonstrating spatial differentiation from 6 * receptor function in the nucleus accumbens

44,45 Myocardial iron overload can cause mitochondrial dysfunction and impaired mitochondrial dynamics, leading to heart failure and arrhythmia

Cellular and Molecular Life Sciences, 57: 18251835

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