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Children under age 18 must have at least one weight-related health condition and their BMI must be in the 95th percentile for their age and sex based on current Centers for Disease Control and Prevention (CDC) charts

Campbell, J.D., et al
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A 2026 review published in Andrology consolidated the mechanistic evidence: kisspeptin modulation of GnRH pulsatility represents a testable biomarker pathway for differentiating PMOS from functional hypothalamic amenorrhea, and potentially for targeted therapeutic intervention

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Zoggel HV, Carpentier G, Santos CD, et al
