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3.3.2 MGBA and anxiety disorders Emerging evidence highlights the MGBA as a critical contributor to anxiety pathophysiology ( NCAM1, CADM2 , and PHF2/FAM120A also correlate with anxiety and mood disorders (Eijsbouts et al., 2021)

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Additionally, excessive production of ROS can degrade and redistribute tight junction proteins, such as ZO-1 and occludin, via the Akt/ASK1/p38 MAPK signaling pathway

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In G6PD-normal red cells, the NADPH is produced by the action of glucose 6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) enzymes

Loss of tight junction integrity and increased intestinal permeability to macromolecules are associated with the pathogenesis of IBD, IBS and celiac disease