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doi: 10.7554/eLife.70934.sa2 375 SchlegelA

Establishment of animal models and behavioral studies for autism spectrum disorders

MNGIE, Mitochondrial Neurogastrointestinal Encephalomyopathy

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Markova NG, Karaman-Jurukovska N, Dong KK, Damaghi N, Smiles KA, and Yarosh DB

Disturbed iron metabolism triggers the Fenton reaction and induces the accumulation of ROS, accumulation of lipid peroxides, and insufficient Glutathione Peroxidase 4 (GPX4) leading to the difficult conversion of lipid hydroperoxides are at the core of the ferroptosis induced by iron metabolism disorders
