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Endocrine Versus Paracrine Autocrine IGF-I One of the controversies of the area has been the relative contribution to linear growth of circulating endocrine IGF-I largely produced by the liver versus peripherally produced IGF-I with major paracrine/autocrine actions on local tissues

Conversely, mice liver with CCl 4 -induced fibrosis showed significantly decreased NQO1 protein expression with respect to controls (Zhu et al

doi: 10.3390/molecules23112983 194 HeYLiWHuGSunHKongQ

(2013) 162(3 Suppl):S4855

doi: 10.1136/gut.2004.060426
Glutathione inhibits tyrosinase activity, reducing unwanted pigmentation and allowing for gradual skin lightening and even tone