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Opportunities for progress include rational brain-exposure design with efflux avoidance, development of microglia-directed delivery systems, and incorporation of human target-engagement biomarkers into early-phase studies

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Interestingly, incubation of PK-8 cells with gemcitabine alone significantly increased glycolysis and induced a decrease in mitochondrial functions, which may be one of the factors leading to PC cell drug resistance

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More specifically, it will make it so that youd have to have lower glucose levels (i.e
