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Removing IKK2 from non-microglial CNS cells also prevents the loss of oligodendrocytes at weeks 3 and 5 compared to wild-type animals treated with cuprizone, suggesting that NF-B pathway-derived cytokines aggravate demyelination in the cuprizone model [181]

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Particularly among the elderly, those with untreated hearing loss are less likely to participate in social activities and more likely to report levels of depression and anxiety (Bess et al., 2009)