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Description

The concentration of the primary antibodies was 1:1,000 for anti-SigA, anti-Rv0884c, anti-p-S6K1, anti-S6K1, anti-Sec13 and anti-WDR24

Mouse experiments were performed under a protocol approved by the Ethics Committee of Tongji Hospital, Tongji Medical College

Sci Rep-Uk 10(1):593 Suzuki T, Yoshinaga N, Tanabe S (2011) Interleukin-6 (IL-6) Regulates Claudin-2 Expression and Tight Junction Permeability in Intestinal Epithelium

Hargis, and Lisa R

Attribute: Sourcing and quality standards Values: Manufacturer origin: Pharmaceutical-grade complex from Ichimaru Pharcos, Japan Botanical sourcing: Globally acclaimed rare flower extracts (peony, scutellaria, saxifraga) selected for skin lightening properties Quality certification: BFAD-certified ingredient meeting international cosmetic safety standards Active preservation: Cold-extraction protocols maintaining bioactive integrity of botanical compounds Clinical validation: Proven efficacy in reducing hyperpigmentation and promoting even-toned, radiant skin Industry recognition: Used by established local and international cosmetic brands for over 20 years Recommended Dosage and Use Attribute: Therapeutic dosing parameters Values: Concentration: 2% Claire Blanche II in topical or oral supplement formulations Administration timing: Daily use as part of comprehensive skin brightening regimen, preferably applied morning and evening Results timeline: Visible reduction in pigment spot area and melanin intensity within 4-6 weeks of consistent application Optimization protocol: Combine with broad-spectrum UV protection (SPF 30+) to prevent new pigmentation while existing spots fade Long-term benefits: Sustained use promotes accelerated cell turnover, maintaining brighter, more even-toned skin Safety, Side Effects, and Interactions Attribute: Safety profile and clinical validation Values: Clinical safety status: BFAD-certified and validated for cosmetic use with established safety profile Toxicity advantage: Delivers melanin inhibition benefits without toxicity and potential side effects associated with single-agent brightening compounds Botanical tolerance: Natural plant-derived actives generally well-tolerated with minimal irritation risk Rare sensitivities: Potential mild reaction in individuals with allergies to compositae family plants or specific botanical extracts