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If Ventricular fibrillation is inadvertently caused through CPR, this perfusion will be lost

Since the response is dose-sensitive and even biphasic, careful studies test a spread of concentrations across several orders of magnitude rather than betting on one number

It represents the negative logarithm of the acid dissociation constant (Ka), which indicates the tendency of a molecule to donate or accept protons in a chemical reaction

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It remains to be elucidated whether there is relationship between this risk locus and any pathogenic mechanisms linked to the skin fibrosis in diffuse SSc