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Although pioglitazone is recommended for patients with biopsy-proven NASH, the efficacy and safety of the drug in the long-term demands more studies ( Reference Chalasani, Younossi and Lavine 72 )

Similar to intestinal enterocytes, brain endothelial cells exhibit apicobasal polarity, meaning that the apical and basolateral plasma membranes possess different protein and lipid compositions (Worzfeld and Schwaninger, 2016)

In contrast to the findings in previous research, in our study, no significant difference was found in the combined monotherapy, when compared to the SGA monotherapy group

& de Bono, J
Memczak S, Papavasileiou P, Peters O, Rajewsky N
