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To realize the successful clinical translation of MNPs as novel bone and joint disease therapies, several emerging areas with the potential to overcome the current limitations of MNP-based nanomedicine are garnering increasing attention (Fig

Osorio, C.E

it is not FDA-approved and not for human consumption

[DOI] [PMC free article] [PubMed] [Google Scholar] 1095.McKenzie JC, Berman NE, Thomas CR, Young JK, Compton LY, Cothran LN, Liu WL, Klein RM

doi: 10.22462/04.06.2020.2

It could be responsible for maintaining homeostasis between DNA damage, senescence, and apoptosis under oxidative stress ( SIRT1 is redistributed at the chromatin level, causing deregulation at the transcription level and DNA damage ( SIRT-1 mRNA expression and induces apoptosis ( SIRT-1 can regulate cellular survival through its role in controlling iron hemostasis
