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These findings highlight an important metabolic trade-off, suggesting that excessive augmentation of cysteine or GSH pools may not always be beneficial and could limit the efficacy of antioxidant-based therapeutic strategies

Sensitivity analyses were performed to address missing data, which were assumed to be missing at random

Alternatively, the lingering low level of hypoxia (67, 68)

cysteine 3

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J Med Chem 51:66426645 Tsiakitzis K, Papagiouvannis G, Theodosis-Nobelos P, Tziona P, Kourounakis PN, Rekka EA (2017) Synthesis, antioxidant and anti-inflammatoy effects of antioxidant acid amides with GABA and N-Acyl-pyrrolidin-2-ones