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Contextual Variables Published dosing patterns are influenced by factors such as: body weight of the research model species differences (rodent vs in-vitro systems) delivery method measurement endpoints (angiogenesis, fibroblast activity, inflammation markers, etc.) These variables limit direct comparison between studies

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doi: 10.1016/j.cll.2013.11.001

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Wells Fargos plan had more than 340,000 participants at the end of 2019