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Heinrichs, M

Carraway K

Type 1 or type 2 errors in studies of TSPO-binding PET radioligand uptake in brain could potentially be explained by the following methodological confounds: Standard neuroimaging techniques were not designed for brainstem study The first-generation radioligand PK11195 has high non-specific binding and low signal-to-background ratio PET signal calculated with an anatomical reference brain region relies on equal radioligand uptake in that region across cases and controls Radioligand access to brain is modified by general metabolism, which can differ across cases and controls Activated peripheral immune cells bind radioligand and can differ in quantity across cases and controls A single nucleotide polymorphism (SNP) in the TSPO gene causes differential radioligand binding Use of healthy controls harms discriminant validity Here, we will address each of these issues and describe solutions

Mol Cell Endocrinol 303(12):1324 Reed MC, Thomas RL, Pavisic J, James SJ, Ulrich CM, Nijhout HF et al (2008) A mathematical model of glutathione metabolism

[Google Scholar] 433.Nakayama J., Kiryu H., Urabe K., Matsuo S., Shibata S., Koga T., Furue M