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Abstract Background Transthyretin (TTR) amyloidosis is a progressive, life-threatening disorder caused by extracellular deposition of amyloid fibrils derived from the plasma protein TTR

The mechanisms included a decrease in food intake, lipogenesis, oxidative stress, inflammation, inhibition of adipocyte differentiation, and a concurrent increase in lipolysis, and fatty acid oxidation

Trimethylamine N-oxide exacerbates cardiac fibrosis via activating the NLRP3 inflammasome

2 If the sleep-wake cycle is compromised, cortisol levels fluctuate, which could result in an increased risk of high blood pressure

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J.O'ByrneC.McLagganD.BoothI