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However, GPx1 does not have the same effects as GPx4 [66, 67]

Others, such as corynoxine, target upstream phosphatases such as protein phosphatase 2A to dually inhibit AKT signaling (98), whereas Gboxin and its analog Y9 trigger lysosomal dysfunction and autophagic impairment (99)

De Nardo D, Labzin LI, Kono H, Seki R, Schmidt SV, Beyer M, et al

While the study could not demonstrate a survival benefit from combination therapy, an analysis of time to treatment failure was favorable toward the prednisone/cyclophosphamide group

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