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Materials and Methods Animals Specific pathogen-free male C57BL/6 mice were purchased from Liaoning Changsheng Biotechnology Company (Benxi, China) and were maintained under controlled conditions (indoor temperature: 22 1C and humidity: 40 60%) and a 12-h dark-light cycle

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2,3 Correction of deficiency different routes of administration Depending on the cause of the deficiency, different strategies to correct it can be applied, although in conventional medical practice the most common treatment is intramuscular (i.m.) injection of B12