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Description
Obese Zucker rats treated with AOD-9604 at 500 mcg/kg/day for 19 days showed a statistically significant reduction in body fat compared to vehicle-treated controls
Mice with more fat had more NNMT
These inhibitors include the low affinity, non-covalent inhibitor carba-NAD and ara-NAD (Table 1)
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Dosing tiers: Epitalon protocols are short and intense: 10 to 20 consecutive days, repeated two to three times per year
GLP-1 agonists are FDA-approved medications with extensive clinical data, while 5-amino-1MQ remains a research compound
