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However, during inflammatory reactions, exposure of macrophages to interferon (IFN) and TNF results in the activation of the inducible isoenzyme of NOS (iNOS), which increases up to 10 times the levels of nitric oxide

10.1038/s41423-022-00905-x 423 WertzI

But several have already been well established, including balancing and regulating the immune system, reducing oxidative stress, inhibiting inflammation, acting as an anticoagulant, scavenging free radicals, improving neurotransmitters signaling in the brain, supporting detoxification, and altering the activities of enzymes, receptors, and related transcription factors

4-(Methyinitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

Ther Drug Monit 45:823826

As our understanding of GST gene families in plants and animals has expanded, this original classification system has had to be refined