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Most research studies have shown that intranasally administered lipophilic compounds improve CNS bioavailability and reduce the time for the onset of therapeutic response

Hypoxia has recently been shown to downregulate thiamine transporters in a colonic cell line, impairing the thiamine uptake that results in a localized intracellular deficiency (190)

Glucose-6-Phosphate Dehydrogenase Deficiency (which will be covered primarily in the hematology section) is a deficiency of a key enzyme in the pentose phosphate shunt that limits the creation of NADPH

A deficiency in either of these nutrients can lead to megaloblastic anemia, a condition in which red blood cells become abnormally large and do not function properly

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While existing studies (2,4) predominantly focused on the anabolic aspects of GSH metabolism, the catabolic process of GSH has received limited attention (10,11)