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This explains the shift from a depolarizing to a hyperpolarizing effect

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M., Strub, M

It is worth emphasizing that the hypoxia microenvironment induced by the E-P-OS network itself can directly activate the transcription of glycolysis-related genes such as glucose transporter 1 and lactate dehydrogenase A via HIF-1, thereby further enhancing glycolysis and ensuring energy supply for fibroid cells under hypoxic conditions [108]

These findings are supported by in vitro research by Finamore et al

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