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Ann Intern Med 133:752753 Yamaura Y, Nakajima M, Takagi S, Fukami T, Tsuneyama K, Yokoi T (2012) Plasma microRNA profiles in rat models of hepatocellular injury, cholestasis, and steatosis
If they start to dip, it might be time to increase their frequency for a bit
For long-term studies, this can sometimes present practical challenges, especially if high frequency of administration is required

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doi: 10.1155/2014/869269
Diet and the Development of the Human Intestinal Microbiome
