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While GSCs in the perivascular niche rely mostly on glucose metabolism, glutamine dependency has been seen in the mesenchymal GSCs residing in hypoxic niche ( These dynamic metabolic changes in GSCs create a challenge when selecting therapeutic targets, and warrants exploration of targeting multiple pathways simultaneously

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Disruption of this exchange mechanism could perturb NADH/NAD + in both compartments and thus could affect cellular redox homeostasis and energy metabolism (Fig