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The medication also carries warnings involving pancreatitis, diabetic retinopathy complications, acute kidney injury due to volume depletion, severe gastrointestinal adverse reactions, gallbladder disease, and other safety considerations

[DOI] [PubMed] [Google Scholar] 20.Ziegler D., Papanas N., Vinik A.I., Shaw J.E

This underdiagnosis can lead, besides death in 20% when it is not appropriately treated, to Korsakoffs syndrome, a severe dysfunction often following untreated Wernickes encephalopathy, that does not remit even with thiamine treatment and is associated with chronic alcohol abuse and chronic thiamine deficiency (, , , )

Because B12 is essential for myelin synthesis and the proper degradation of catecholamines, researchers conclude that this deficiency directly impairs sympathetic nervous system baroreceptor function

Chronic inflammation, which leads to pain and disability, is thought to be a dysregulation of an appropriate inflammatory process

Some people who do not get enough B12 naturally in their diet