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While effective, it can cost thousands to tens of thousands of dollars annually

Small molecule derivatives of 4-amino-quinoline, in particular, are non-covalent and demonstrate an IC50 values in the nanomolar range (103, 104) and include three lead compounds: 78c (IC50 7.3 nM), 1ai (IC50 46 nM), and Iah (IC50 115 nM)

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One obvious limitation is that how someone behaves when every sip they are taking is under close observation may not necessarily reflect what happens in a much looser, real-world social setting