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112 Other functional changes characterized by the bacterial dysbiosis typical of the condition are elevated branched-chain amino acid metabolism, along with elevated methane metabolism, enhanced degradation of xenobiotics and stimulated sulphate reduction

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Biochimie 165, 250257

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However, in senescent ECs, eNOS activity declines, leading to impaired NO production and dysfunction [9, 118, 119]

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Moreover, sorafenib, a first-line therapy for advanced hepatocellular carcinoma, shows limited clinical benefit

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