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Thus, 4-1BB, compared with CD28, remarkably haltered CAR-T cell exhaustion and improved CAR-T cell function [95, 103]

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Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimers disease

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In addition to the effects on oxidative balance, alterations in cysteine levels have also been shown to modulate neurotransmitter pathways, including glutamate and dopamine [33, 34]

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Additional ideas for targeting melanoma persisters include using senolytics 47 as well as limiting tumor plasticity with persister state-directed transitioning 35

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