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In rare cases, this can complicate the monitoring of malignant changes such as melanoma, potentially delaying diagnosis

For persons who continue to inject illicit drugs, especially if they share needles and other drug-use equipment, it is likely that the risks of treatment will outweigh the benefits even if they are "willing and able." This is true despite the potential publichealth benefit of reducing transmission to others

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Nat Rev Endocrinol 15 (2), 105125