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M., Lambert, A

An imbalance between the supply and demand of oxygen [141,142,143] in the arterial wall leads to a hypoxic plaque microenvironment, mainly arising from the combination of increased cellular metabolic demand and reduced oxygen diffusion caused by thickening of the arterial wall during the development of atherosclerotic lesions [144]

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(iii) MDA is not generated exclusively through lipid peroxidation

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Through screening, they identified 10 natural hydroxyflavonoid compounds, including flavone and nine of its mono- or polyhydroxy derivatives (3-HF, 5-HF, 3,7-DHF, chrysin, 7,3,4-THF, fisetin, luteolin, quercetin, and morin), as suitable for the MALDI-FTICR-MS analysis and imaging of endogenous lipids in the mouse liver in positive ion mode