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doi: 10.1016/S0005-2736(02)00633-8

In addition, stevioside suppresses inflammation by downregulating the IB/NF-B, MAPK, and TLR4-mediated immune signaling pathways, reducing the release of IL-6, TNF-, interleukin-1 beta (IL-1), and nitric oxide (NO) ( Stevioside enhances mitochondrial bioenergy metabolism by inducing PGC-1 expression, promoting fatty acid oxidation, reducing fat accumulation, and improving insulin sensitivity, thereby contributing to metabolic homeostasis (Park et al., 2022a)

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Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice

doi: 10.3390/ijms232214478 67 EltzschigH