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Exogenous administration of synthetic Ec peptides leads to phosphorylation of extracellular signal regulated kinases (ERK1 and ERK2), serine/threonine-specific protein kinase (Akt), IGF-1 and insulin receptor-independent cell growth [16] and produces mitogenic effect on human cell lines [17,18]
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doi: 10.1016/j.injury.2018.12.027
[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Herzog RW, et al

For example, severe dehydration may require intravenous (IV) fluids