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Changes in Coagulation Factors Semaglutide, the active ingredient in Ozempic, may indirectly influence coagulation pathways

The frequency of MTHFR homozygous genotype 677CC was 89% in the vitamin B-12 group and 85% in the placebo group ( P = 0.18), and the frequency of homozygous 677TT was 0.6% in both groups ( P = 1.00)

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Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis

doi:10.1161/JAHA.122.026723