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Sci Adv (2021) 7:eabj0364
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Ubiquitination is a hierarchical cascade of enzymatic reactions catalyzed by three enzymes ubiquitin-activating (E1), ubiquitin-conjugating (E2), and ubiquitin-ligating (E3) enzymes ( Figure 2 2.2 Non-Keap1-mediated regulation In addition to the Keap1 signaling pathway, other signaling pathways can also affect the transcription of Nrf2 ( Figure 2 )
Sobolev AN
Abnormal liver enzymes: A review for clinicians
