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Cao X, Scoffield J, Xie B et al (2023) Drosophila melanogaster as a model to study polymicrobial synergy and dysbiosis

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observed that exogenous glutamate inhibits cystine uptake through the cystine/glutamate antiporter system, depleting GSH and inducing an increase in ROS levels and intracellular Ca2+ influx, causing a form of programmed cell death in neuronal cells distinct from apoptosis ( The concept of ferroptosis was first proposed by Dixon et al ( As a form of RCD, ferroptosis differs from apoptosis, necrosis, autophagy, and other forms of cell death

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Sclerostin [a sclerosteosis ( SOST ) gene product] is an essential component of the negative regulator in bone development, and osteocytes and osteoblasts may play a major role

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