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Interestingly, chemical compounds extracted from mushrooms can also be used as agents that act indirectly to inhibit signs of skin aging

Its smaller molecular structure allows efficient diffusion in tissue models, facilitating localized cellular interactions

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Evidence includes: Stimulation of endothelial and keratinocyte migration Enhanced blood vessel density in wound healing models Promotion of stem cell differentiation toward repair cell lineages Low molecular weight enabling tissue penetration over long distances Unlike growth factors that bind to extracellular matrix, TB-500s mobility allows systemic distribution to multiple injury sites

Linnerbauer M, Llein L, Vandrey O, Peter A, Han Y, Tsaktanis T et al (2024a) The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology