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In a study of patients with chronic low back pain, Vitamin B12 given for 2 weeks reduced pain by 32% compared to placebo [Chiu, 2011] In a 2020 systematic review looking at the use of B12 for nerve-related pain it was found that there is moderate evidence for the therapeutic effect of B12 in the treatment painful peripheral neuropathy [Julian, 2020]

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What the Evidence Shows This is the question most people want answered directly: does B12 deficiency cause hair loss, and will fixing it help

however, this study did not provide mitochondrial function measurements 325

B12 is essential for brain function and beneficial for sleep and mood, and can help people suffering from depression and fatigue