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Treated mice showed significant reductions in body weight and white adipose tissue mass compared to untreated controls on the same high-fat diet

The question was whether those functions could be separated

Additionally, AOD9604 does not exert diabetogenic (leading to development of diabetes) side effects

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Because of its ability to use NAD + as a substrate, CD38 has been hypothesized to act as a metabolic sensor, limiting the duration of NAD + half-life and signaling in the extracellular compartment
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Without it, the engine still exists, but it doesnt fire properly
