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Central to these processes are the synthesis of purines (adenine and guanine) and thymidylate (an intermediate for de novo synthesis of thymidine), which are critical components of DNA replication and repair, and the regulation of amino acid homeostasis [2,3]

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These genes include cathepsin G, CEA cell adhesion molecule 8, complement C3b/C4b receptor 1, integrin subunit alpha, C-C motif chemokine ligand 5

154 WangM.MaoC.OuyangL.LiuY.LaiW.LiuN.et al (2019c)

The results of immunostaining and western blot showed that an obvious increased protein expression of 4-HNE was found in peroxynitrite treated SGNs, while it was significantly decreased in peroxynitrite + ebselen group but further increased in peroxynitrite + gpx1 / mice compared with the peroxynitrite-only group (Figures 5B,C)

Exposure to As-, Cd- and Pb-mixture induces A, amyloidogenic APP processing and cognitive impairments via oxidative stress-dependent neuroinflammation in young rats