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Under physiological conditions, Nrf2 remains sequestered in the cytoplasm by its inhibitor, the Kelch-like ETC-associated protein 1 (Keap1), but oxidative or electrophilic stress triggers Nrf2 dissociation, nuclear translocation, and binding to antioxidant response elements (AREs), upregulating genes such as heme oxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), and glutathione S-transferases (GSTs) (Cuadrado et al., 2019)

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By slowing this process down, youll also feel full for longer after eating, leading to some people using Ozempic as a weight-loss drug, though this use is off-label and not approved by the FDA

Vitamin B12, in particular, is known for its role in energy metabolism

Marianes, A

and Palanivelu K., The Effect of Curcumin (Turmeric) on Alzheimer's Disease: An Overview, Annals of Indian Academy of Neurology 11, no