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By aligning their catalytic palm subdomains, we observed that the rest of the subdomains from the RdRp domain (NTD, fingers and thumb), along with the PRNTase domain and the attached VP35 tetramer, exhibited very slight rotations relative to those in the published EBOV LVP35 structures, which results in the inward movement of each (sub)domains by approximately 2.0 to 4.8 (Fig
Pixel quantification of images was achieved using Image J and statistics were performed using Prism 5 and InStat v.3.05
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On the contrary, the incidence of the abnormal HPA axis in the PT group significantly decreased after treatment ( 2 = 8.769, P = 0.003)
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Whats more, conformational changes are also observed in the supporting helix of the palm subdomain
