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at the same time, andrographolide can activate adenylate cyclase to promote the formation of cAMP and activate protein kinase A (PKA) to promote glycogen synthase kinase-3 (GSK-3) phosphate inactivation of HO-1, which weakens the negative regulation of Nrf2 by GSK-3 and maintains the continuous activation of HO-1 ( 4.3 Liver fibrosis Any liver injury will develop into liver fibrosis during the healing process, and if the condition persists for a long time, it can develop into liver cirrhosis

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Targeting Amino Acid Metabolic Reprogramming via L-Type Amino Acid Transporter 1 (LAT1) for Endocrine-Resistant Breast Cancer

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