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10.1039/c9fo02451d Food Funct

Drug Metabol Drug Interact 23:5168 Yao Y, Xu G, Mou D, Wang J, Ma J (2012) Subcellular Mn compartation, anatomic and biochemical changes of two grape varieties in response to excess manganese

Yet, despite its relevance, the relationship of betaine and choline to homocysteine metabolism has been only lightly investigated in humans, essentially because the choline content of foods could not be accurately measured until fairly recently

Major risk factors include chronic hepatitis B and C virus infections [4], alcohol abuse, aflatoxin B1 exposure, diabetes mellitus, obesity, tobacco use, iron accumulation, and nonalcoholic fatty liver disease [10]

most other claimed benefits (bone density, body composition) trace back to animal studies or preliminary/anecdotal reports, not confirmed human efficacy trials

Furthermore, this effect is dose-dependent