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GSDMD-N forms pores in the plasma membrane, causing osmotic imbalance, cytoplasmic content leakage, and pyroptosis execution

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The link between elevated circulating proteasome levels and disease activity has also been demonstrated in patients with systemic autoimmune diseases

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1 Introduction Osteoarthritis (OA) is a highly prevalent and destructive degenerative joint disease, affecting approximately 7.6% of the global population, with over 595 million cases in 2020 alone (Martel-Pelletier et al., 2016