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Downregulation of GS is not due to protein degradation but rather the inhibition of protein synthesis Since NH 4 Cl has previously been reported to induce autophagy in mouse embryo fibroblasts and tumor cells 17,18,19 , we wondered if GS downregulation in astrocytes upon glutamate and NH 4 Cl co-treatment was due to protein degradation

In NF1, children are predisposed to low-grade glial cell tumors (gliomas) of the optic pathway and brainstem, whereas in NF2, tumors of the cranial nerves, especially vestibular schwannomas, meninges (meningioma) and spinal cord (ependymomas) are more typical. An important aspect of managing NF1 and NF2 is treating the associated tumors, adds pediatric neuro-oncologist Tanya Tekautz, MD, in Cleveland Clinics Department of Pediatric Hematology/Oncology and Blood and Bone Marrow Transplantation

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Start with reduced intensity, duration, and frequency compared to your pre-injury levels