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A two-fold increase in mutagenicity was observed after feeding Drosophila with 1 to 5% MC in 2% diethylsulfoxide [71]

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For the protein kinase deletion mutant screen, strains were grown in 1 mL liquid YPD medium using a 24-well plate and incubated for overnight at 30 C with shaking at 180 rpm

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The implication of these findings is that excess removal of hydrogen peroxide contributes to reductive stress that promotes protein misfolding and aggregation and the resulting cardiac dysfunction

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