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However, the research also noted a complication
However, to be defined as Future Smart Food (FSF), NUS are required to present four core attributes simultaneously: nutritional richness (improving nutrition), climate resilience (increasing environmental sustainability), local availability/adaptability, and cost-effectiveness (income generation, reducing workload) ( NUS includes many food groups such as cereals, legumes, vegetables, tree products, fruits, oilseeds, roots, and tubers (Table 1) (198)

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On one hand, iron overload markedly enhances the accumulation of reactive oxygen species (ROS) in cerebral endothelial cells, leading to downregulation of ferroportin 1 (FPN1) and impaired iron efflux
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